Artemisinin Biosynthesis in Non-glandular Trichome Cells of Artemisia annua

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The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.

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This paper reviews the use of whole-plant Artemisia annua (sweet Annie) as it pertains to malaria including history, chemistry, clinical efficacy, pharmacokinetics, dosing, safety, and resistance. Artemisinin, the sesquiterpene lactone found in the plant, and various semi-synthetic variants of it used as critical drugs around the world for malaria are discussed in comparison to the whole plant....

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ژورنال

عنوان ژورنال: Molecular Plant

سال: 2019

ISSN: 1674-2052

DOI: 10.1016/j.molp.2019.02.011